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題目：Post-transcriptional gene regulation and ???deregulation in human diseases

報告人：陳煒 教授

陳煒教授個人簡介：德國MAX?DELBRüCK分子醫(yī)學(xué)中心

Dr. Chen obtained his Ph.D. degree from Max-Planck-Institute for Molecular Genetics in 2006. He trained in human molecular genetics and bioinformatics. Between 2007 and 2008, he stayed at the same institute and led a research group. His group developed one of the first experimental and data analysis pipelines for Illumina/Solexa sequencing. At 2009, he moved to the newly established Berlin Institute for Medical Systems Biology at Max-Delbrueck-Center for Molecular Medicine, where he led the genomics platform. His lab has been developing various genomic assays based on the novel sequencing technology. The research interest of his lab is to understand the mechanisms underlying post-transcriptional gene regulation and their important role in causing human diseases

1. Wang, Y., Gogol-D?ring, A., Hu, H., Fr?hler, S., Ma, Y., Jens, M., Maaskola, J., Murakawa, Y., Quedenau, C., Landthaler, M., Kalscheuer, V., Wieczorek, D., Wang, Y., Hu, Y. and Chen, W (2013) Integrative analysis revealed the molecular mechanism underlying RBM10-mediated splicing regulation. EMBO Mol Med. 2013 doi:?10.1002/emmm.201302663
2. Sun W, You X, Gogol-D?ring A, He H, Kise Y, Sohn M, Chen T, Klebes A, Schmucker D, Chen W (2013) Ultra-deep profiling of alternatively spliced Drosophila Dscam isoforms by circularization-assisted multi-segment sequencing. EMBO J. 2013 Jun 21. doi: 10.1038/emboj.2013.144. [Epub ahead of print]
3. Schwanh?usser B, Busse D, Li N, Dittmar G, Schuchhardt J, Wolf J*, Chen W*, Selbach M*. (2011) Global quantification of mammalian gene expression control Nature. 2011 May 19;473(7347):337-42
4. Adamidi C, Wang Y, Gruen D, Mastrobuoni G, You X, Tolle D, Dodt M, Mackowiak SD, Gogol-Doering A, Oenal P, Rybak A, Ross E, Alvarado AS, Kempa S*, Dieterich C*, Rajewsky N*, Chen W * (2011) De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics. Genome Res 21(7):1193-200

主持人：洪岸教授

時? 間：2014年5月12日（星期一）下午3：00

地? 點：暨南大學(xué)第二理工樓701會議室

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