????? ????????￡???±?±???????|?·???′?3???§???o???????????§???§???o???|???2???±?????????????????1?o?1?o???￠???????o???????????oNIH???????′?μ?????￥???????????????1?2?????3?±?2?????????o?????·?￡??????Human Molecular Genetics?￡?¨HMG?￡???????·?￠?±?-???????￠???a???°A calcineurin- and NFAT-dependent pathway is involved in ???-synuclein-induced degeneration of midbrain dopaminergic neurons.???±?μ???????????￡???????3???????????μ?·?????????????￡?¨calcineurin?￡?????????°?????????μ??NFAT?????o?????¨???·???????-synuclein???1?????μ?????????°???-?2?????ˉ???ˉ???￡?????????·?￠???????????????a?μ?????·?????￡???±?±???????|?·???′?3???§???·???a?μ???????μ?￥???????￡
?????????? ???????°???-?2???????3?????a???°?2???????±???￡?????????????????°???????????????????ˉ???????|?μ?????????????±???-???μ???3???????????2?2?????￡???????￠?1?o????????????????James Parkinson?μ?????????o????1817???a???????????¨???????￡???????°???-?2???μ???2?????-?????±?¤???·???a?????????????o???????o???????°???￡???????′?|?????°???°?·???????±???-???a???????????±???§?o???±?¤???????￡???￠???????±???-?????°???±?¤???????1?μ???????μ???????°???°?·???±?·?|?￡?????????????°?±???2???μ???2?????-???ˉ???§?????±?¤?μ???1?????????￡?2?????3?±?2???????????1?????μ?????±???-?????′?????§???μ???????????·???a????????Pitx3/A53T ?|??-synuclein???a???1???2???????3???′?????????????????????°???°?·???????±???-???a???a???§?μ?????·???a???o???????￡???|???2???±???????????°???¤?o?????·?????·?￠?????????|??-synuclein???1?????μ???????°???°?·???????±???-???°?????????￡???????μ?·???????????????°???¤????????NFAT?????o?????¨???·?′?|???????¤???????′???????￡???￠???a?????????????o???μ?????-???￠???????°???-?2???μ???·?￠?2?????o???????????°???°???????????|?μ?????????ˉ?????????°???μ?￡?????1?????????????μ?μ?????μ???????1?′?????￡
?????????? ?????1?¤???·?μ???μ???????????1?o?1?o???￠???????o???????????o???????????1???°???￠?1?o???????????????????§???1???°???????°?1?o???????′???§???1???°???ˉ???????a?1?????????????|?3???1?o?????????????????μ???′?3???|???§?3?????￡
???????????????????′?????￡?ohttp://hmg.oxfordjournals.org/cgi/reprint/ddu377?
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