A facile and sensitive colorimetric detection for RNase A activity based on target regulated protection effect on plasmonic gold nanoparticles aggregation
Wang, R (Wang, Rui); Yu, RZ (Yu, Renzhong); Wang, ZY (Wang, Zhaoyin); Zhu, QS (Zhu, Qinshu)[ 1 ]*; Dai, ZH (Dai, Zhihui)[ 1 ]*(戴志暉)
[ 1 ] Nanjing Normal Univ, Sch Chem & Mat Sci, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Nanjing 210023, Peoples R China
[ 2 ] Nanjing Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Biofunct Mat, Nanjing 210023, Peoples R China
SCIENCE CHINA-CHEMISTRY,202003,10.1007/s11426-020-9702-1
In this work, a facile and sensitive colorimetric detection method was firstly reported for RNase A activity detection based on target regulated protection effect of chimeric DNA probe on the salt-induced aggregation of plasmonic gold nanoparticles. Compared with previous works of RNase A activity detection, this colorimetric assay integrated the advantages of sensitive, low cost, facile operation, rapid response and low biological toxicity.
文章鏈接:
https://link.springer.com/article/10.1007/s11426-020-9702-1
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