李淑萍教授課題組和沈健教授課題組合作在 COLLOIDS AND SURFACES A發(fā)表研究論文
Synthesis of hollow mesoporous HAp-Au/MTX and its application in drug delivery
Zhen-Lei Liu[ 1 ], Qing-Yang Jia[ 1 ], Xiao-Dong Li[ 1 ], Shu-Ping Li[ 1 ]*（李淑萍）, Jian Shen[ 1 ]*（沈?。? Jun Lin[ 1 ],Dong-Xiang Li[ 2 ]
[ 1 ]Jiangsu Key Laboratory of Biofunctional Material, College of Chemistry and Material Science, Nanjing Normal University, Nanjing, 210023, China
[ 2 ]State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao,
266042, China
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS，202002,586
A hollow mesoporous microspheres of hydroxyapatite-Au containing the anticancer agent of methotrexate
(hmHAp-Au/MTX) were prepared here. Firstly, biocompatible hydroxyapatite nanoparticles (NPs) with a hollow
core and mesoporous shell structure (hmHAp) were synthesized by a template method. Secondly, Au NPs were
successfully conjugated onto the surface of hmHAp through the electrostatic attraction. The synthesized hmHApAu/MTX had high biocompatibility and pH responsive features. Moreover, the drug release of hmHAp-Au/MTX
was pH-dependent because of the dissolution of HAp under acidic conditions. Furthermore, the combined
treatment on the cancer cells by using hmHAp-Au/MTX for synergistic hyperthermia ablation and chemotherapy
was demonstrated to exhibit higher therapeutic efficacy, presenting the great potential of the platform for cancer
therapy.
文章鏈接：
https://www.sciencedirect.com/science/article/abs/pii/S0927775719312269?via%3Dihub
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