周林副教授、魏少華教授課題組在JOURNAL OF MATERIALS CHEMISTRY B發(fā)表研究論文
Oxyhemoglobin nano-recruiter preparation and its application in biomimetic red blood cells to relieve tumor hypoxia and enhance photodynamic therapy activity
Shi, XQ (Shi, Xianqing)[ 1 ] ; Zhan, QC (Zhan, Qichen)[ 1 ] ; Yan, XH (Yan, Xiaohong)[ 1 ] ; Zhou, JH (Zhou, Jiahong)[ 1 ] ; Zhou, L (Zhou, Lin)[ 1 ]*（周林）; Wei, SH (Wei, Shaohua)[ 1 ]*（魏少華）
[ 1 ] Nanjing Normal Univ, Key Lab Appl Photochem, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Coll Chem & Mat Sci,Jiangsu Key Lab Biofunct Mat, Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China
JOURNAL OF MATERIALS CHEMISTRY B，202001,8(3),534-545
Photodynamic therapy (PDT) is strongly O-2 dependent. Therefore, its therapeutic effects are seriously hindered in hypoxic tumors. Red blood cells are responsible for delivering O-2 in the blood. In this manuscript, biomimetic red blood cells (BRBCs) were exploited using a layer-by-layer assembly method, using Fe3O4@CuO, oxyhemoglobin (OxyHb), a photosensitizer and a photo-cross linked acrylate modified hyaluronic acid (HA) gel shell. The Fe3O4@CuO core has very high OxyHb loading efficiency (the adsorption capacity of Fe3O4@CuO for OxyHb is derived to be 0.99 mg mg(-1)) to ensure a sufficient O-2 supply. OxyHb was protected well by the HA shell in order to avoid O-2 release during the delivery process in blood before arrival at the tumor tissue. The HA shell protection can be eliminated in position at the tumor to trigger O-2 release through hyaluronidase (HAase) triggered HA degradation. Furthermore, Fe3O4 in the nanosystem can provide magnetic field assisted tumor targeting and magnetic resonance imaging of the tumor. Therefore, this work presents a highly efficient all-in-one biomimetic nanomedicine approach to overcome hypoxia and achieve tumor targeting theranostics.
文章鏈接：
https://pubs.rsc.org/en/content/articlelanding/2020/TB/C8TB02430H#!divAbstract
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