吳萍副教授和蔡稱心教授課題組在CHEMISTRY OF MATERIALS發(fā)表研究論文
Enhancing the Plasmon Resonance Absorption of Multibranched Gold Nanoparticles in the Near-Infrared Region for Photothermal Cancer Therapy: Theoretical Predictions and Experimental Verification
Hu, YJ (Hu, Yaojuan)[ 1 ] ; Liu, XY (Liu, Xiaoyan)[ 1 ] ; Cai, ZW (Cai, Zhewei)[ 3 ] ; Zhang, H (Zhang, Hui)[ 1 ] ; Gao, H (Gao, Han)[ 1 ] ; He, WJ (He, Wenjing)[ 1 ] ; Wu, P (Wu, Ping)[ 1 ]*（吳萍）; Cai, CX (Cai, Chenxin)[ 1 ]*（蔡稱心）; Zhu, JJ (Zhu, Jun-Jie)[ 2 ]*; Yan, ZJ (Yan, Zijie)[ 3 ]*
[ 1 ] Nanjing Normal Univ, Jiangsu Key Lab New Power Batteries, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Coll Chem & Mat Sci, Nanjing 210097, Jiangsu, Peoples R China
[ 2 ] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Life Sci, Nanjing 210093, Jiangsu, Peoples R China
[ 3 ] Clarkson Univ, Dept Chem & Biomol Engn, Potsdam, NY 13699 USA
CHEMISTRY OF MATERIALS，201901,31(2),471-482
Multibranched gold nanoparticles (M-AuNPs) can serve as photothermal agents for near-infrared (NIR) photothermal therapy (PTT) of cancer, but a major shortcoming is that they tend to strongly scatter NIR light, causing a significant reduction in absorption. This work addresses this issue, based on theoretical simulations and experimental determinations, to enhance the absorption and reduce the scattering of these materials by screening their structural parameters. Our finite-difference time-domain simulations predict that M-AuNPs with a core size of similar to 25 nm, a tip number of 5, and a tip height of similar to 40 nm (i.e., an aspect ratio of similar to 2) are optimal for trapping NIR light and yielding the highest light-to-heat conversion efficiency (eta) and for trapping NIR light of various polarization and incident directions. The predicted M-AuNPs were synthesized by a seed-mediated growth method, and the measured optical properties agreed well with the simulation results. The M-AuNPs were further used as photothermal agents for in vitro killing of MCF-7 cells and in vivo ablation of tumors constructed on nude mice. Nearly all cells died after they were incubated with M-AuNPs and irradiated under an 808 nm laser at a 1.0 W cm(-2) for 10 min. The tumors on the nude mice were also effectively ablated without regrowth during the observation period (20 days) after PTT.
文章鏈接：
https://pubs.acs.org.ccindex.cn/doi/10.1021/acs.chemmater.8b04299
版權(quán)與免責(zé)聲明：本網(wǎng)頁的內(nèi)容由收集互聯(lián)網(wǎng)上公開發(fā)布的信息整理獲得。目的在于傳遞信息及分享，并不意味著贊同其觀點(diǎn)或證實(shí)其真實(shí)性，也不構(gòu)成其他建議。僅提供交流平臺，不為其版權(quán)負(fù)責(zé)。如涉及侵權(quán)，請聯(lián)系我們及時(shí)修改或刪除。郵箱：sales@allpeptide.com