黃湧課題組成功設(shè)計新型的三氮烯導(dǎo)向基團(tuán)
??? 碳?xì)滏I的活化及官能團(tuán)化，由于可以提供最直接，最原子經(jīng)濟(jì)學(xué)的藥物分子后期修飾，是目前化學(xué)合成領(lǐng)域的研究熱點之一。黃湧課題組最近成功設(shè)計新型的三氮烯導(dǎo)向基團(tuán)實現(xiàn)了碳?xì)浠罨c官能團(tuán)化，研究成果以封面形式發(fā)表在德國應(yīng)用化學(xué)雜志（影響因子：13.5）。該研究的亮點在于新設(shè)計的導(dǎo)向基團(tuán)可以進(jìn)行一系列化學(xué)官能團(tuán)的轉(zhuǎn)化，克服了目前碳?xì)浠罨袑?dǎo)向基團(tuán)必須殘留在產(chǎn)物結(jié)構(gòu)中的瓶頸。
?
Due to its versatile application to straightfoward and atom economical late stage functionalization of drug candidates, C-H activation/functionalization has emerged as one of the hottest research fields of chemical synthesis. Recently, Yong Huang et. al from SCBB invented a novel triazene directing group for C-H activation and functionalization, published as cover page in the upcoming issue of Angewandte Chemie International Edition (impact factor: 13.5). The highlight of this work lies under the versatility of this newly designed directing group to undergo a series of chemical transformation after C-H activation. It overcomes a vital limitation of this state-of-the-art technology, in which the directing group has to remain part of its products!
?
版權(quán)與免責(zé)聲明：本網(wǎng)頁的內(nèi)容由收集互聯(lián)網(wǎng)上公開發(fā)布的信息整理獲得。目的在于傳遞信息及分享，并不意味著贊同其觀點或證實其真實性，也不構(gòu)成其他建議。僅提供交流平臺，不為其版權(quán)負(fù)責(zé)。如涉及侵權(quán)，請聯(lián)系我們及時修改或刪除。郵箱：sales@allpeptide.com