??? 在最近一期的Molecular Biosystems雜志上，化學(xué)生物學(xué)與生物技術(shù)學(xué)院的林碩、楊震和仲寒冰三個(gè)課題組合作發(fā)表了一篇論文《Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling》。這篇論文中，作者首先采用斑馬魚(yú)模型篩選到了一個(gè)小分子GSK3抑制劑，隨后用有機(jī)合成方法進(jìn)一步改造這個(gè)抑制劑，最終得到一類具有新骨架的抑制劑，并研究了這些抑制劑在胚胎發(fā)育中的作用。論文信息見(jiàn)下。
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On the latest issue of Molecular Biosystems, three groups (Dr. Lin, Dr. Yang and Dr. Zhong) in School of Chemical Biology and Biotechnology published a paper titled “Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling”. In this paper, the authors employed zebrafish as a model to screen chemical libraries and identified a small-molecule GSK3 inhibitor, which was further modified by organic synthesis approaches to create new generation GSK3 inhibitors with novel scaffold. The information of the paper is below.
Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling
Hanbing Zhong, Haixia Zou, Mikhail V. Semenov, Deborah Moshinsky, Xi He, Haigen Huang, Song Li, Junmin Quan, Zhen Yang and Shuo Lin,? Mol. BioSyst., 2009, 5, 1356
2009-10-26
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