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Zhang, P (Zhang, Pan)[ 1 ] ; Sun, BH (Sun, Baohong)[ 1,2 ] ; Wu, F (Wu, Fan)[ 1 ] ; Zhang, QC (Zhang, Qicheng)[ 1 ] ; Chu, XH (Chu, Xiaohong)[ 1 ] ; Ge, MQ (Ge, Manqing)[ 3 ] ; Zhou, NL (Zhou, Ninglin)[ 1 ]*（周寧琳） ; Shen, J (Shen, Jian)[ 1 ]*（沈?。?/p>

[ 1 ]? Nanjing Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Biofunct Mat, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Nanjing 210023, Peoples R China
[ 2 ]? Nanjing Tech Univ, Sch Chem & Mol Engn, Nanjing 211816, Peoples R China
[ 3 ]? Nanjing Normal Univ, Sch Food Sci Pharmaceut Engn, Nanjing 210023, Peoples R China

Journal of Materials Science 2021,56,6411-6426

Microorganism invasion is still a severe threat for wound healing, which usually induces severe complications and cannot be eradicated completely. Thus, a biodegradable nanomaterial for guarding against bacteria-associated wound infection and accelerating wound healing is of vital importance. Here, black phosphorus nanosheets (BPs) were successfully decorated with cationic carbon dots (CDs) through an in situ growth strategy. The BPs@CDs exhibit photonresponsiveness and contact-responsiveness as an antibacterial agent, which shorten wound healing time. Moreover, the BPs@CDs show available photothermal and photodynamic therapy via exploring their photothermal properties and the ability of singlet-oxygen (O-1(2)) production. Astonishingly, the BPs@CDs could possess antibacterial activity even without laser illumination due to an electrostatic attraction between bacteria and cationic CDs on the surface of BPs. This chemical therapy causes the antibacterial process to occur more accurately and for a faster O-1(2) release to kill bacteria than in a normal process. Importantly, BPs@CDs display outstanding cytocompatibility and hemocompatibility. In vitro and in vivo investigations demonstrate that the BPs@CDs have enhanced antibacterial effect and can significantly accelerate skin tissue regeneration and wound closure. Given their antibacterial triplecombination therapy and excellent physicochemical properties, the broad application of BPs@CDs in bacteria-associated wound management is anticipated.