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Liu, L (Liu, Li)[ 1 ] ; Peng, W (Peng, Wan)[ 1 ] ; Zhang, X (Zhang, Xiao)[ 1 ] ; Peng, JM (Peng, Jiangmei)[ 1 ] ; Liu, PS (Liu, Pingsheng)[ 1 ]*（劉平生） ; Shen, J (Shen, Jian)[ 1,2 ] *（沈?。?/p>

[ 1 ]? Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Sch Chem & Mat Sci, Jiangsu Key Lab Biofunct Mat, Nanjing 210023, Peoples R China
[ 2 ]? Nanjing Univ, Jiangsu Engn Res Ctr Interfacial Chem, Nanjing 210093, Peoples R China

JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 2021,62,96-106

Developing advanced technologies to address the bacterial associated infections is an urgent requirement for metallic implants and devices. Here, we report a novel phosphonate/quaternary amine block polymer as the high-efficiency antibacterial coating for metallic substrates. Three pDEMMP-b-pTMAEMA block polymers that bearing identical phosphonate segments (repeat units of 15) but varied cationic segments (repeat units of 8, 45, and 70) were precisely prepared. Stable cationic polymer coatings were constructed on TC4 substrates based on the strong covalent binding between phosphonate group and metallic substrate. Robust relationship between the segment chain length of the polymer coating and the antibacterial property endowed to the substrates have been established based on quantitative and qualitative evaluations. Results showed that the antibacterial rate of the modified TC4 surface were 95.8 % of S. aureus and 92.9 % of E. coli cells attached. Interestingly, unlike the cationic free polymer or cationic hydrogels, the surface anchored cationic polymers do compromise the viability of the attached C2C12 cells but without significant cytotoxicity. In addition, the phosphonate/quaternary amine block polymers can be easily constructed on titanium, stainless steel, and Ni/Cr alloy with significantly improved antibacterial property, indicating the generality of the block polymer for surface antibacterial modification of bio-metals. (C) 2020 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.