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Anticoagulant polyurethane substrates modified with poly(2-methacryloyloxyethyl phosphorylcholine) via SI-RATRP

Chi, C (Chi, Cheng)[ 1,2 ] ; Sun, BH (Sun, Baohong)[ 1,2 ] ; Zhou, NL (Zhou, Ninglin)[ 1,2,3 ]*（周寧琳）; Zhang, M (Zhang, Ming)[ 1,2 ] ; Chu, XH (Chu, Xiaohong)[ 1,2 ] ; Yuan, P (Yuan, Ping)[ 1,2 ] ; Shen, J (Shen, Jian)[ 1,2 ]*（沈?。?/span>

[ 1 ] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biol Funct Mat, Coll Chem & Mat Sci, Nanjing 210023, Jiangsu, Peoples R China

[ 2 ] Jiangsu Engn Res Ctr Biomed Funct Mat, Jiangsu Key Lab Biofunct Mat, Nanjing 210023, Jiangsu, Peoples R China

[ 3 ] Nanjing Zhou Ninglin Adv Mat Technol Co Ltd, Nanjing 211505, Jiangsu, Peoples R China

COLLOIDS AND SURFACES B-BIOINTERFACES,201803,163,301-308

A novel catalyst system of Reverse Atom Transfer Radical Polymerization (RATRP) to prepare Polyurethane (PU) films modified by poly(2-methacryloyloxyethyl phosphorylcholine) (pMPC) was studied in this article. In this system, PU film was pretreated by LaCl3/CA ethanol solution to obtain a hydrated surface allowing more initiators to be immobilized on it. Moreover, complexes composed of silane coupling agent 3-chloropropyltrimethoxysilane (CPTM), chlorhexidine acetate (CA) and lanthanum(III) worked as ligands of copper ions as a whole during RATRP process. PU films before and after modification were characterized by X-ray photoelectron spectroscopy (XPS) and static contact angle (SCA) to confirm that pMPC chains were successfully grafted from the substrates. Results of Plasma recalcification time assay, platelet adhesion test indicated excellent blood compatibility. Furthermore, the antibacterial activity of the material have been improved which proved by adhesion test of E.coil.

文章鏈接：

https://www.sciencedirect.com/science/article/pii/S0927776518300055?via%3Dihub