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報告題目：Evolution and virus-host interactions: insights from chikungunya virus

報告人：Rubing Chen博士，美國University of Texas Medical Branch病理系助理教授

時間：2015年5月22日（星期五）下午2：00

地點：生科院3樓圓形會議室

歡迎參加！

Rubing Chen博士簡介：

研究方向：
? ? 結(jié)合計算和實驗生物學(xué)方法來探索病毒的進化和發(fā)生機制，并將研究結(jié)果應(yīng)用于流行病的防治：1）利用分子進化和序列分析方法研究流行病的起源、傳播途徑、進化和種群特征；2）結(jié)合反式遺傳學(xué)方法研究流行病爆發(fā)的機制，包括病毒的宿主適應(yīng)性突變、種群瓶頸效應(yīng)、上位顯性等等因素；3）利用上述結(jié)果進一步研究病毒和宿主的相互作用分子機制，此方向目前集中于研究基肯孔尼雅病毒（chikungunya virus）3’UTR 的功能。?

教育背景：
2005-2009 Pennsylvania State University，博士
2002-2005 陜西師范大學(xué)，碩士
1998-2002 陜西師范大學(xué)，學(xué)士

工作經(jīng)歷：
2015至今 美國University of Texas Medical Branch，Department of Pathology，助理教授?
2009-2014美國University of Texas Medical Branch，Department of Pathology，博士后
2010 ? ? 塞內(nèi)加爾巴斯德研究所，訪問學(xué)者?
2008-2009香港大學(xué)新發(fā)傳染性疾病國家重點實驗室，訪問學(xué)生?

代表論文：
1.?? ?Chen R., Wang E., Tsetsarkin K.A., Weaver S.C. (2013) Chikungunya Virus 3’ Untranslated Region: Adaptation to Mosquitoes and a Population Bottleneck as Major?

Evolutionary Forces. PLoS Pathogens 9: e1003591.?
2.?? ?Chen R., Holmes E. C. (2006) Avian Influenza Virus Exhibits Rapid Evolutionary Dynamics. Molecular Biology & Evolution 23(12): 2336-2341.?
3.?? ?Volk S.M.*, Chen R.*, Tsetsarkin K.A., et al. (2010) Genome Scale Phylogenetic Analyses of Chikungunya Virus Reveal Independent Emergences of Recent Epidemics and?

Varying Evolutionary Rates. Journal of Virology 84(13): 6495-6504. (*contributed equally)?
4.?? ?Chen R., Vasilakis N. (2011) Dengue--quo tu et quo vadis? Viruses 3(9): 1562-608. ?
5.?? ?Chen R., Holmes E. C. (2010) Rapid Fixation of Internal Gene Segments in Avian Influenza Virus due to Genetic Hitchhiking. Journal of Molecular Evolution 70(1): 98-105.?
6.?? ?Chen R., Holmes E. C. (2009) Frequent inter-species transmission and geographic subdivision in avian influenza viruses from wild birds. Virology 383(1): 156-161.?
7.?? ?Chen R., Holmes E. C. (2008) The Evolutionary Dynamics of Human Influenza B Virus. Journal of Molecular Evolution. 66(6): 655-663.?
8.?? ?Hyde J.L.*, Chen R.*, Trobaugh D.W.*, Diamond M.S., Weaver S.C., Klimstrac W.B., Wilusz J. (2015) The 3' and 5' ends of alphavirus RNAs – non-coding is far from non-

functional. Virus Research. (*contributed equally; In press)?
9.?? ?Tsetsarkin K.A., Chen R., Yun R., Rossi S.L. et al. (2014) Multi-peaked adaptive landscape for chikungunya virus evolution predicts continued fitness optimization in?

Aedes albopictus mosquitoes. Nat Commun. 5: 4084?
10.?? ?Tsetsarkin K.A., Chen R., Sherman M.B., Weaver S.C. (2011) Chikungunya Virus: Evolution and Genetic Determinants of Emergence. Curr Opin Virol 1(4): 310-317.?
11.?? ?Tsetsarkin K.A., Chen R., Leal G., Forrester N., Higgs S., Huang J., Weaver S.C. (2011) Chikungunya virus emergence is constrained in Asia by lineage-specific adaptive?

landscapes. Proc Natl Acad Sci U S A 108(19): 7872-7.?
12.?? ?Dugan V.G., Chen R., Spiro D.J., Sengamalay N., Zaborsky J., et al. (2008) The Evolutionary Genetics and Emergence of Avian Influenza Viruses in Wild Birds. PLoS?

Pathogens 4(5): e1000076.?
13.?? ?Bahl J., Nelson M.I., Chan K.H., Chen R., et al. (2011) Temporally structured metapopulation dynamics and persistence of influenza A H3N2 virus in humans. Proc Natl Acad?

Sci U S A 108(48): 19359-64.?