應江蘇省分子醫(yī)學生物技術重點實驗室劉暢教授的邀請,美國輝瑞制藥有限公司旗下心血管、代謝和內分泌疾病研發(fā)部高級科學家周穎江博士來我校訪問,并做學術報告。
報告題目:The Crosstalk between ER Stress and Insulin Signaling
報告人:周穎江 博士 (美國輝瑞制藥有限公司)
時間:2012年12月13日 10:00
地點:生命科學學院三樓圓形會議室
報告人簡歷:周穎江,男,博士,美國輝瑞制藥有限公司高級科學家。2000年在南京大學獲得學士學位,2005年在南京大學分子醫(yī)藥研究所獲得生物化學與分子生物學博士學位,2005-2008年在美國密歇根大學從事博士后研究,2008-2011年在Harvard Medical School 作為研究員從事內分泌研究工作,2011年至今在美國輝瑞制藥有限公司旗下心血管、代謝和內分泌疾病研發(fā)部門擔任高級科學家。目前他的研究方向主要集中于機體內質網應激和胰島素信號轉導交互作用的分子調控機制。
部分代表性論文:
1. Zhou Y, Lee J, Reno CM, Sun C, Park SW, Chung J, Lee J, Fisher SJ, White MF,
Biddinger SB, Ozcan U. Regulation of glucose homeostasis through a XBP-1–FoxO1
interaction. Nature Medicine. 2011; 17: 356–65.
2. Zhou Y, Jiang L, Rui L. Identification of MUP1 as a regulator for glucose and lipid metabolism in mice. The Journal of Biological Chemistry. 2009; 284: 11152–9.
3. Cao J, Zhou Y, Peng H, Huang X, Stahler S, Suri V, Qadri A, Gareski T, Jones J, Hahm S, Perreault M, McKew J, Shi M, Xu X, Tobin JF, Gimeno RE. Targeting acylcoA: diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. The Journal of Biological Chemistry. 2011; 286: 41838–51.
4. Sheng L, Cho KW, Zhou Y, Shen H, Rui L. Lipocalin 13 protein protects against hepatic steatosis by both inhibiting lipogenesis and stimulating fatty acid ?-oxidation. The Journal of Biological Chemistry. 2011; 286: 38128–35.
5. Lee J, Sun C, Zhou Y, Lee J, Gokalp D, Herrema H, Park SW, Davis RJ, Ozcan U. p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis. Nature
Medicine. 2011; 17: 1251–60.
6. Sheng L, Zhou Y, Chen Z, Ren D, Cho KW, Jiang L, Shen H, Sasaki Y, and Rui L. ?NF-kB–inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action. Nature Medicine. 2012; 18: 943–9.
7. Cho KW*, Zhou Y*, Sheng L, Rui L. Lipocalin-13 regulates glucose metabolism by both insulin-dependent and -independent mechanism. Molecular and Cellular Biology. 2011; 31: 450–7. * equal contributions
8. Park SW, Zhou Y, Lee J, Lee J, Ozcan U. Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity. Proceedings of the National Academy Sciences of the USA. 2010; 107: 19320–5.
9. Park SW, Zhou Y, Lee J, Lu A, Sun C, Chung J, Ueki K, Ozcan U. The regulatory
subunits of PI3K, p85? and p85?, interact with XBP-1 and increase its nuclear
translocation. Nature Medicine. 2010; 16: 429–37.
10. Sharara-Chami RI, Zhou Y, Ebert S, Pacak K, Ozcan U, Majzoub JA. Epinephrine deficiency results in intact glucose counter-regulation, severe hepatic steatosis and possible defective autophagy in fasting mice. The International Journal of Biochemistry & Cell Biology. 2012; 44: 905–13.
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