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應(yīng)江蘇省分子醫(yī)學(xué)生物技術(shù)重點(diǎn)實(shí)驗(yàn)室的邀請(qǐng)，美國(guó)國(guó)立衛(wèi)生研究院國(guó)家癌癥研究所的江永平博士來(lái)我校訪問(wèn)，并做學(xué)術(shù)報(bào)告。

報(bào)告題目：Prevention and Treatment of Cancer with Our Own Immune System

報(bào)告人：江永平 博士 （美國(guó)國(guó)立衛(wèi)生研究院國(guó)家癌癥研究所）

時(shí)間：2012年11月16日 下午3：00

地點(diǎn)：生命科學(xué)學(xué)院三樓多功能報(bào)告廳

報(bào)告人簡(jiǎn)歷：江永平，男，博士。1984年在南京師范大學(xué)獲得學(xué)士學(xué)位，1987年在中國(guó)科學(xué)院動(dòng)物研究所（北京）獲得動(dòng)物學(xué)碩士學(xué)位，1996年在University of Nebraska Medical Center獲得生物化學(xué)和分子生物學(xué)博士學(xué)位。

學(xué)術(shù)兼職：

·??????? Steering committee member for NCI fellows and young investigators, 2002 - 2005

·??????? Steering committee member of Chinese NIH Immunology Interest Club, 2002 – present

·??????? Manager of Chinese NIH Immunology Interest Club, 2003-2004, 2010 - present

·??????? Member of the American Association of Immunologists, 2000 – 2004

·??????? Member of the NIH Immunology Interest Group, 1997 – 2003

部分代表性論文：

·???????? Chiang* YJ and Hodes RJ?? 2011?? Cbl enforces Vav1 dependence and a restricted pathway of T cell development.??? PLoS ONE 6(4): e18542? (*Corresponding author)

·???????? Martiniova L, J. Lu, J. Chiang, M. Bernardo, R. Lonser, Z. Zhuang, K. Pacak? ???2011 ??Pharmacologic Modulation of Serine/Threonine Phosphorylation Highly Sensitizes PHEO in a MPC Cell and Mouse Model to Conventional Chemotherapy.? PLoS ONE 6: e14678

·???????? Lu J, Chiang J, Iyer RR, Thompson E, Kaneski CR, Xu DS, Yang C, Chen M, Hodes RJ, Lonser RR, Brady RO, Zhuang Z? 2010??? Decreased glucocerebrosidase activity in Gaucher disease parallels quantitative enzyme loss due to abnormal interaction with TCP1 and c-Cbl.? PNAS 107: 21665-70

·???????? Chiang* YJ, Calado RT, HathcockKS, Lansdorp PM, Young NS and Hodes RJ?? 2010 ?Telomere length is inherited with resetting of the telomere set-point. ?PNAS 107: 10148. (*Corresponding author)

·???????? Jang IK., Zhang J., Chiang YJ, Kole, H., Cronshaw DG, Zou Y. and Gu, H.?? 2010?? Grb2 Functions at the Top of the TCR-induced Tyrosine Kinase Cascade to Control Thymic Selection. PNAS 107: 10620-25.?

·???????? Wen J, Chiang*, YJ, Gao C, Xue H, Xu J, Ning Y, Hodes RJ, Gao X, Chen YG.?? 2010?? Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice. J. Biological Chemistry 285: 11023-30? (*Co-first author)

·???????? Lu J, Kovach JS, Johnson F, Chiang J, Hodes R, Lonser R, Zhuang Z.? 2009 Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms. ?PNAS 106:14734

·???????? Scharner D, R?ssig L, Carmona G, Chavakis E, Urbich C, Fischer A, Kang TB, Wallach D, Chiang YJ, Deribe YL, Dikic I, Zeiher AM, Dimmeler S??? 2009? Caspase-8 Is Involved in Neovascularization-Promoting Progenitor Cell Functions.?? Aterioscler Thromb Vasc Biol 29: 571-578

·???????? Chiang*, Y.J., M. S. Jordan, R. Horai, P. L. Schwartzberg, G. A. Koretzky, and R. J. Hodes?? 2009? Cbl Enforces an SLP76-dependent Signaling Pathway for T Cell Differentiation. J. Biological Chemistry 284: 4429-4438?? (*Corresponding author)

·???????? Nakamura, A., J.Y. Chiang, K.S. Hathcock, I. Horikawa, O.A. Sedelnikova, R.J. Hodes and W.M. Bonner? 2008? Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence. Epigenetics & Chromatin 1: 6

·???????? Chiang*, Y. J., S. J. Hsiao, D. Yver, S.W. Cushman,? Lino Tessarollo, Susan Smith and R. J. Hodes? 2008?? Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development.? PLoS ONE 3: e2639? (*Corresponding author)

·???????? Chiang, Y. J., I.K. Jang, R. J. Hodes and H. Gu?? 2007?? Ablation of Cbl-b provides protection against inoculated and spontaneous tumors. J. Clinical Investigation 117: 1029-36

·???????? Cheng, A., K. Shin-ya, T. Miura, S.-C. Tang, R. Wan, H. Tang, R. Khatri, M. Gleichman, X. Ouyang, D. Liu, H.-R. Park , J. Y. Chiang, and M. P. Mattson?? 2007? Telomere Protection Mechanisms Change During Neurogenesis and Neuronal Maturation:? Newly Generated Neurons are Hypersensitive to Telomere and DNA Damage.? J. Neuroscience 24: 3722-33

·??????? H. Song, L. Zhang, Y. J. Chiang, R. Siraganian, R. J. Hodes? 2007? Redundancy in B cell developmental pathways: c-Cbl inactivation rescues early B cell development through a BLNK-independent pathway. J. Immunology 178: 926-35