作者：李文清、孫春陽、王峰、王育才、翟儀穩(wěn)、梁猛、劉文靜、劉志民、王均、孫斐
DOI: 10.1021/nl400536d
Abstract：
During the process of human civilization, more and more pets have entered our family. Many unwanted dogs and cats may be reservoirs or vectors of transmissible diseases to human. Confronted with the over-population of pets, the traditional contraception methods for animals are the surgical methods of sterilization, namely ovariohysterectomy and orchidectomy. Therefore, a simple, non-surgical, controllable, more effective and less expensive contraception method is highly desirable. In this study, we show that in situ testicular injection of methoxy poly(ethylene glycol)-modified gold nanorods with near-infrared irradiation in male mice can achieve short-lived or permanent male infertility. In a lower hyperthermia treatment, the morphology of testes and seminiferous tubules is only partly injured, and fertility indices are decreased to ~ 10% at day 7, then recovered to 50% at day 60. In a higher hyperthermia treatment, the morphology of testes and seminiferous tubules are totally destroyed, and fertility indices are decreased to 0 at day 7. Overall, our results indicate a potential application of plasmonic nanomaterials on male contraception.
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