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細(xì)胞可滲透的、不可逆的 caspase-1 (ICE) 抑制劑。N.Rouquet 等。表明Ac-YVAD-CMK是一種有效的治療小鼠體內(nèi)肝細(xì)胞凋亡的藥物。
編號:169055
CAS號:178603-78-6
單字母:Ac-YVAD-CMK
編號: | 169055 |
中文名稱: | Caspase 1 Inhibitor II |
英文名: | Caspase 1 Inhibitor II |
CAS號: | 178603-78-6 |
單字母: | Ac-YVAD-CMK |
三字母: | Ac-Val 纈氨酸 -Ala丙氨酸 -Asp天冬氨酸 -CMKC端氯甲基酮修飾 |
氨基酸個數(shù): | 4 |
分子式: | C24H33O9N4l1 |
平均分子量: | 521.54 |
精確分子量: | 521.22 |
等電點(diǎn)(PI): | 7.01 |
pH=7.0時的凈電荷數(shù): | - |
平均親水性: | -0.6 |
疏水性值: | 0.4 |
外觀與性狀: | 白色粉末狀固體 |
消光系數(shù): | 1490 |
來源: | 人工化學(xué)合成,僅限科學(xué)研究使用,不得用于人體。 |
純度: | 95%、98% |
鹽體系: | 可選TFA、HAc、HCl或其它 |
儲存條件: | 負(fù)80℃至負(fù)20℃ |
標(biāo)簽: | CMK(氯甲基酮)修飾 |
Cell-permeable, irreversible inhibitor of caspase-1 (ICE). N.Rouquet et al. showed that Ac-YVAD-CMK is a potent therapeutic agent against in vivo liver apoptosis in mice.
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