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178603-78-6,PASE-1 抑制劑 II; Ac-Tyr-Val-Ala-Asp-CMK,Ac-Tyr-Val-Ala-Asp-CMK,Ac-YVAD-CMK,杭州專肽生物的產(chǎn)品

Caspase 1 Inhibitor II

細(xì)胞可滲透的、不可逆的 caspase-1 (ICE) 抑制劑。N.Rouquet 等。表明Ac-YVAD-CMK是一種有效的治療小鼠體內(nèi)肝細(xì)胞凋亡的藥物。

編號:169055

CAS號:178603-78-6

單字母:Ac-YVAD-CMK

糾錯
  • 編號:169055
    中文名稱:Caspase 1 Inhibitor II
    英文名:Caspase 1 Inhibitor II
    CAS號:178603-78-6
    單字母:Ac-YVAD-CMK
    三字母:Ac

    N端乙?;舛?/p>-Tyr

    酪氨酸

    -Val

    纈氨酸

    -Ala

    丙氨酸

    -Asp

    天冬氨酸

    -CMK

    C端氯甲基酮修飾

    氨基酸個數(shù):4
    分子式:C24H33O9N4l1
    平均分子量:521.54
    精確分子量:521.22
    等電點(diǎn)(PI):7.01
    pH=7.0時的凈電荷數(shù):-
    平均親水性:-0.6
    疏水性值:0.4
    外觀與性狀:白色粉末狀固體
    消光系數(shù):1490
    來源:人工化學(xué)合成,僅限科學(xué)研究使用,不得用于人體。
    純度:95%、98%
    鹽體系:可選TFA、HAc、HCl或其它
    儲存條件:負(fù)80℃至負(fù)20℃
    標(biāo)簽:CMK(氯甲基酮)修飾   

  • Cell-permeable, irreversible inhibitor of caspase-1 (ICE). N.Rouquet et al. showed that Ac-YVAD-CMK is a potent therapeutic agent against in vivo liver apoptosis in mice.

  • DOI名稱
    10.1164/ajrccm.159.4.9712012LPS challenge in D-galactosamine-sensitized mice accounts for caspase-dependent fulminant hepatitis, not for septic shock下載
    10.1038/sj.bjp.0703629Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses下載
    10.1107/s0907444900009884Crystallization and preliminary X-ray diffraction analysis of a recombinant cysteine-free mutant of crmA下載
    10.1111/j.1349-7006.2003.tb01358.xEvodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells下載
    10.1038/sj.cdd.4401247Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity下載
    10.1254/jphs.fpj03102xDracorhodin perchlorate induces apoptosis via activation of caspases and generation of reactive oxygen species下載
    10.1248/bpb.27.1527Oridonin induces a caspase-independent but mitochondria- and MAPK-dependent cell death in the murine fibrosarcoma cell line L929下載
    10.1080/09674845.2004.11732672Induction of apoptosis in myeloid progenitors by granulocyte-macrophage colony-stimulating factor下載
    10.1016/j.cell.2006.07.033Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival下載
    10.1016/j.surneu.2007.03.041Neuroprotective effects of Ac.YVAD.cmk on experimental spinal cord injury in rats下載
    10.1016/j.cellbi.2008.08.021Cadmium toxicity in cultured tomato cells--role of ethylene, proteases and oxidative stress in cell death signaling下載
    10.1002/eji.201142268IL-18 associates to microvesicles shed from human macrophages by a LPS/TLR-4 independent mechanism in response to P2X receptor stimulation下載
    10.1016/j.brainres.2014.04.019Chemical stimulation of the intracranial dura activates NALP3 inflammasome in trigeminal ganglia neurons下載
    10.1371/journal.ppat.1004599Uropathogenic Escherichia coli superinfection enhances the severity of mouse bladder infection下載
    10.1046/j.1365-2567.2000.00921.xCD95 ligand expression as a mechanism of immune escape in breast cancer下載
    10.1046/j.1462-5822.2001.00162.xSalmonella pathogenicity island 2-dependent macrophage death is mediated in part by the host cysteine protease caspase-1下載
    10.1248/bpb.26.1543Intracellular regulation of evodiamine-induced A375-S2 cell death下載
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