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250584-13-5,四肽Cbz-DEVDCMK,Cbz-Asp-Glu-Val-Asp-CMK,Z-DEVD-CMK,杭州專(zhuān)肽生物的產(chǎn)品

四肽Cbz-DEVDCMK

Z-DEVD-CMK reversibly inhibits caspase-3.

編號(hào):158243

CAS號(hào):250584-13-5

單字母:Z-DEVD-CMK

糾錯(cuò)
  • 編號(hào):158243
    中文名稱(chēng):四肽Cbz-DEVDCMK
    CAS號(hào):250584-13-5
    單字母:Z-DEVD-CMK
    三字母:Cbz

    N端Cbz保護(hù)

    -Asp

    天冬氨酸

    -Glu

    谷氨酸

    -Val

    纈氨酸

    -Asp

    天冬氨酸

    -CMK

    C端氯甲基酮修飾

    氨基酸個(gè)數(shù):4
    分子式:C27H35O13N4l1
    平均分子量:623.59
    精確分子量:623.22
    等電點(diǎn)(PI):-
    pH=7.0時(shí)的凈電荷數(shù):-3
    平均親水性:1.875
    疏水性值:-1.58
    外觀與性狀:白色粉末狀固體
    消光系數(shù):-
    來(lái)源:人工化學(xué)合成,僅限科學(xué)研究使用,不得用于人體。
    純度:95%、98%
    鹽體系:可選TFA、HAc、HCl或其它
    儲(chǔ)存條件:負(fù)80℃至負(fù)20℃
    標(biāo)簽:CMK(氯甲基酮)修飾    CBZ修飾肽   

  • Z-DEVD-CMK reversibly inhibits caspase-3.

  • DOI名稱(chēng)
    10.1038/sj.cdd.4401247Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity下載
    10.1016/j.chembiol.2004.11.010Using a small molecule inhibitor of peptide: N-glycanase to probe its role in glycoprotein turnover下載
    10.1074/jbc.M408475200Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin下載
    10.1152/ajpheart.00338.2008Activation of caspase-3 may not contribute to postresuscitation myocardial dysfunction下載
    10.1038/cddis.2011.139Paclitaxel resistance is associated with switch from apoptotic to autophagic cell death in MCF-7 breast cancer cells下載
    10.1006/excr.1997.3928Multiple intracellular pathways interfere with the activation of a CPP32-like protease induced by serum deprivation of AKR-2B cells下載
    10.1016/s0014-5793(98)00424-4Caspases disrupt mitochondrial membrane barrier function下載
    10.1074/jbc.273.47.31245Tumor necrosis factor induces ceramide oscillations and negatively controls sphingolipid synthases by caspases in apoptotic Kym-1 cells下載
    10.1016/s0167-4838(02)00333-3Probing the caspase-3 active site by fluorescence lifetime measurements下載
    10.1038/sj.onc.1206694Early events in the induction of apoptosis in ovarian carcinoma cells by CD437: activation of the p38 MAP kinase signal pathway下載
    10.1007/BF03033795Death and neuroprotection of retinal ganglion cells after different types of injury下載
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