NH2-PEG4-Val-Cit-PAB-OH是一種可裂解的ADC連接體，具有伯胺、親水性PEG間隔區(qū)、Val-Cit二肽和PAB基團(tuán)。PAB上的芐醇可用于連接反應(yīng)性基團(tuán)，如PNP，以與藥物有效載荷結(jié)合。伯胺可以自由地進(jìn)行多種反應(yīng)，例如與羧酸偶聯(lián)、與酮或醛還原胺化，或其他更專業(yè)的用途，例如在SNAr反應(yīng)或雜環(huán)化學(xué)中。Val-Cit二肽被細(xì)胞內(nèi)的細(xì)胞蛋白酶切割，以允許通過(guò)PAB結(jié)構(gòu)內(nèi)的消除機(jī)制進(jìn)行有效的有效載荷遞送。

NH2-PEG4-Val-Cit-PAB-OH is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.